There are three cities by the name of San Diego, as you have not mentioned the exact one that you wanted to know, I will provide you with the distances for all three.
- The distance between San Diego, California and San Francisco is 453 in miles or 729 in kilometers.
- The distance between San Diego, Texas and San Francisco is 1548 miles or 2491 in kilometers.
- The distance between San Diego, Carabobo, Venezuela and San Francisco is 3949 in miles or 6355 in kilometers.