You can take Interstate 10 from New Orleans all the way to Houston, the drive time should take five or six hours and it's about three hundred fifty miles. :)
Driving Directions From New Orleans, La. To Houston, Tx. What's The Driving Directions & Mileage?
1: Start out going SOUTHWEST on DECATUR ST toward ST PETER ST.
0.2 mi
2: Turn RIGHT onto ST LOUIS ST.
0.5 mi
3: Turn RIGHT onto BASIN ST.
0.1 mi
4:Stay STRAIGHT to go onto ORLEANS AVE.
0.4 mi
5: Merge onto I-10 W toward BATON ROUGE/ NEW ORLEANS INT'L AIRPORT.
80.1 mi
6:Keep LEFT to take I-10 E toward LAFAYETTE (Crossing into TEXAS).
266.6 mi
7: End at Houston, TX
Estimated Time: 5.0 hours 30 minutes
Estimated Distance: 348.86 miles
0.2 mi
2: Turn RIGHT onto ST LOUIS ST.
0.5 mi
3: Turn RIGHT onto BASIN ST.
0.1 mi
4:Stay STRAIGHT to go onto ORLEANS AVE.
0.4 mi
5: Merge onto I-10 W toward BATON ROUGE/ NEW ORLEANS INT'L AIRPORT.
80.1 mi
6:Keep LEFT to take I-10 E toward LAFAYETTE (Crossing into TEXAS).
266.6 mi
7: End at Houston, TX
Estimated Time: 5.0 hours 30 minutes
Estimated Distance: 348.86 miles