The straight line distance between Tuscaloosa, Alabama, United States and Meridian, Mississippi, United States is just 88 miles or 143 kilometers. The driving distance between the two cities is however a bit longer, it is 96.1 miles and it is almost a one hour and 35 minutes drive. When you leave Tuscaloosa, head northeast on Paul W Bryant Dr E toward AL-215/University Blvd E and after that turn left to merge onto AL-6/McFarland Blvd/US-82. After driving for almost 2.5 miles you will have to take the ramp onto I-20 W/I-59 S that enters Mississippi and later on you will have to take the exit 154 for MS-39/MS-19. When you reach MS 39, take a right turn. When you reach Front St Ext/MS-39, take a left turn. After that turn right at 24th Ave/MS-493 and again turn left at 20th St.